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Specifically, they assessed whether its use was safe and improved weight loss, metabolic, and comorbidity outcomes, including 10-year atherosclerotic cardiovascular disease [ASCVD] risk

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That small molecular size is the defining advantage: these peptide fragments can cross the blood-brain barrier and interact directly with neurons, something that most endogenous neurotrophic factors cannot do on their own

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Physiol Res (2011) 60(6):94150