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The hepatotoxic effect of VPA metabolites has been well studied [23,24]

3.3 Novel formulations and delivery systems The most recent stage of GLP-1RA development has been focused on novel delivery mechanisms and formulations to improve patient comfort and compliance

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However, whether peripheral mechanisms, together with or independent of other central pathways, also participate in morphine-induced colonic hypomotility requires further investigation in future studies

Yang XM, Downey JM, Cohen MV, Housley NA, Alvarez DF, Audia JP