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(II) biosynthesis and activation of antioxidant enzymes
Also, intracellular, oxidants are produced as an effect of the combined environmental exposure described the exposome, which involves molecular factors such as toxicants, nutrients, drugs, and pollutants as well as physical stressors (UV, X-ray, and other ionizing radiation) and psychological stressors (lifestyle)
Primary glutamatergic deficit, likely originating from aberrant neuron-glia interactions, leads to an early GSH excess via diversion of GSH-glutamate metabolic pathways
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