More importantly, a recent article by Youssef et al., who investigated a small series of normal and G6PD-deficient subjects with COVID-19, highlighted a reduced survival rate among G6PD-deficient patients compared to normal ones
doi: 10.1007/s13300-021-01078-y
doi:10.1016/j.vaccine.2007.09.066
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Under oxidative stress and induced by excessive ROS generation, Nrf2 is released from its inhibitor Keap1, allowing its translocation into the nucleus (Kasprzak et al., 2020), where it binds to the antioxidant response element (ARE) present in the DNA sequence of numerous antioxidant enzymes like glutathione-S-transferase, -glutamyl cysteine synthetase (glutamate cysteine ligase), heme oxygenase 1, and paraoxonase-1 inducing their transcription, managing the phase II response to oxidative stress (Kasprzak et al., 2020)
These factors are indispensable for processes like collagen production, cell proliferation, and the migration of cells to injury sites, all of which are essential for effective soft tissue healing