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This approval was based on the SURPASS clinical trial program, which demonstrated superior glycemic control compared to placebo, semaglutide 1 mg, and insulin degludec across multiple studies

Rare heterozygous loss-of-function variants in the human GLP-1 receptor do not associate with cardiometabolic phenotypes

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Murphy CC, Correa AM, Ajani JA, Komaki RU, Welsh JW, Swisher SG , Hofstetter WL

PMID: 11 CoatesLCSorianoERCorpNBertheussenHCallis DuffinKCampanholoCBet al