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Glucagon receptor activation appears counterintuitive in obesity and diabetes therapy because glucagon acutely increases hepatic glucose output

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It helps control blood sugar and support weight loss by working on GLP-1 and GIP receptors

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Notably, certain commensals, like Clostridium cluster XIVa and segmented filamentous bacteria, have the ability to push the host immune system toward regulatory responses via regulatory Treg expansion and IL-10 production (Touchefeu et al., 2014)