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[4] In the SURMOUNT-1 obesity trial, a 72-week placebo-controlled study in 2,539 adults with obesity (without diabetes), mean weight change was 15.0%, 19.5%, and 20.9% at the 5, 10, and 15 mg doses versus 3.1% for placebo

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For example, it has been shown that melanocyte-stimulating factors, such as -MSH, ET-1, or ACTH, can remain upregulated for several months to years following repeated UV exposure, long after visible pigmentation has faded 17

This observation of microbial shift may contribute to the excessive gut inflammation