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The analysis revealed that weight loss accounted for only 13% and 21% of the improvement in HOMA2-IR with tirzepatide (10 mg and 15 mg, respectively), indicating that weight loss was only partially responsible for the observed improvements in insulin resistance

Rare but Serious Side Effects While rare, semaglutide can cause more serious side effects

However, the medication can typically be kept at room temperature (below 86F / 30C) for up to 21 days if necessary

Therefore, long term use may be necessary for some people to keep lost weight off

Hannah Beba, consultant pharmacist in diabetes at West Yorkshire Health and Care Partnership, raised issues around the practicality of administration following the results

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