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9,10 An algorithm for treating TNF alpha inhibitor psoriasiform eruptions has been proposed and is based on severity of skin eruption and control of the underlying disease 11 : If the skin eruption is mild and the underlying disease is controlled, continue the TNF alpha inhibitor and treat the eruption topically If the skin eruption is mild but the underlying disease is not controlled, switching within the same class is reasonable If the skin eruption is moderate to severe and the underlying disease is controlled, switching within the same class is reasonable If the skin eruption is moderate to severe and the disease is not well controlled, discontinuing TNF alpha inhibitors altogether is warranted

Topical formulations have also demonstrated measurable effects on pigmentation

Cell 14 (1), 7685 (2008)

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