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The resulting enhancement of connective tissue integrity makes it a key focus in musculoskeletal regeneration and aging-related bone metabolism research

In addition, mild spongy changes in hypothalamic nuclei were noticed, and the ependymal cell layer of the third ventricle is loosely packed and appeared scattered

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Preclinical dosing in the cited literature is reported in micrograms-per-kilogram body weight, which does not translate to a specific human-scale dose

doi: 10.1016/j.cmet.2017.08.011

Namely, vitamin C has been found to decrease skin aging on both intrinsic and extrinsic levels