A 2026 retrospective study of US patients found tirzepatide produced 11.2% weight loss at 6 months versus 8.8% for semaglutide
Semaglutide should not be used in patients with a history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2
While every medication comes with potential side effects, phentermine is less likely to cause these types of issues, making it a better option for patients who are sensitive to gastrointestinal discomfort
Maintaining appropriate hydration is essential for patients taking GLP-1 medications, particularly given the common gastrointestinal side effects that can affect fluid balance
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These then feel like confirmation that the medication is causing problems, which increases the worry further
