2 Recognizing the need for comprehensive, person-centered obesity care, the World Health Organization's 2026 global guidelines explicitly recommend pairing GLP-1 therapies with intensive behavioral interventions, including weekly counseling sessions and structured goal setting for diet and physical activity
GLP-1 Weight Loss Expectations: Both options exceed expectations when combined with a healthy diet and exercise
Tirzepatide and retatrutide are also glucose-dependent insulinotropic polypeptide (GIP) agonists
These medicines mimic the action of glucagon-like peptide-1 (GLP-1), a naturally occurring incretin hormone produced in the intestine in response to food intake
Mori S, Tomita T, Fujimura K, et al
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