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Evaluation of seasonal heat stress on transcriptomic profiles and global DNA methylation of bovine oocytes

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doi: 10.1074/jbc.M404984200

The synergy between exogenous MOTS-c and exercise is not merely additive: because MOTS-c mimics one of the molecular consequences of high-intensity exercise (AMPK activation via AICAR accumulation), concurrent exercise training may amplify the peptide's effects on GLUT4 translocation and mitochondrial biogenesis

BMC Psychiatry 20, 92

Consistency is often more important than intensity