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DLL4 secreted by tip cells activated Notch signaling in the neighboring endothelial cells, suppressing tip cell formation by inhibiting VEGFR2 and VEGFR3 expression and inducing VEGFR1 (decoy for VEGF) expression [14,15,16,17]

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3 Nanoparticle-loaded with cytotoxic chemotherapeutic drugs Despite TMZ being the sole chemotherapeutic agent currently used in glioblastoma treatment (as first line) there are a lot of other promising therapeutic cargoes for nanoparticles

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