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Sleep Deprivation + Oxidative Ageing Replenish with Phytos + Restore Your Sleep When poor sleep begins to show up on the skin, this duo helps restore overnight repair

An ER stress sensor, ATF6 is cleaved from its full-length (~90 kDa) form to its active cleaved form (~50 kDa) in a thapsigargin-induced ER stress environment 41

Its receptor, GLP-1R is a member of class B GPCRs (G protein-coupled receptors) which are characterized by a seven transmembrane domain at their C-termini and a large extra-cellular domain at their N-termini 27,28,29,30

Multi-receptor activation (GLP-1, GIP, glucagon)

Pros: Affects skin tone globally

3 GLP-1 is also produced in cerebral preproglucagon neurons, where it is released locally and acts as a neurotransmitter