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A schematic representation of the TGFR-1 signaling pathway for renal fibrosis is depicted in Fig

Study on the quaternary structure suggested that rhGPx3 mutant existed as a monomer in solution, which is different from native tetrameric GPx3

Thus we have targeted the dimerization process by developing molecules that mimic the dimerization domain, the hinge region, with idea that they can act as dominant negative replacements

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Meanwhile, HT significantly increased soluble protein content, proline and malondialdehyde (MDA) content as well as O 2 production rate, the gene expression and activities of antioxidant enzymes

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