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As body composition changesparticularly with loss of adipose tissuethermoregulation is affected because fat serves primarily as insulation, while heat generation comes largely from metabolically active lean tissue

For people with severe renal impairment (eGFR below 30 mL/min/1.73 m) or those on dialysis, the evidence base for most weight loss medications is limited, and many are either contraindicated or lack sufficient safety data

Safety is vital, and healthcare professionals play a crucial role in personalized treatment plans, monitoring, and counseling

The people who developed these complications were typically very ill: critically unwell patients in intensive care, individuals with indwelling central venous catheters, or people with severe neutropenia or profound immune suppression