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Eli Lilly had made early attempts to modify the fatty acid side chain of GLP-1, but did not make a mark in the field

On the other hand, opposing evidence suggests that the use of GLP-1 RAs does not increase the risk of pulmonary aspiration in the peri-procedural setting

Tirzepatide has less breast milk excretion data than semaglutide

doi: 10.5114/pg.2020.95554 Damianos JA, Fredrick TW, Jin MF, Ospina-Velasquez L, Wang XJ

1 More recently, additional pathophysiologic mechanisms have been identified that are implicated in contributing to impaired glucose homeostasis and the varied metabolic alterations associated with T2DM

Additionally, all of the metabolic improvements while on the medication were also reversed