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Activation of oncogenes such as RAS and MYC, along with metabolic reprogramming phenomena like the Warburg effect, further amplify intracellular ROS generation, establishing a reinforcing cycle that perpetuates tumor development [34]

Sforzo, G

Furthermore, hormonal adaptations contribute significantly to plateaus

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Gandhi AV, Mosser EA, Oikonomou G, Prober DA (2015) Melatonin is required for the circadian regulation of sleep