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Compared to monotherapy, the combination group had higher rates of overweight/obesity, type 2 diabetes, hypertension, and hyperlipidemia, but lower rates of ischemic heart disease, heart failure, and atrial fibrillation

This approach mirrors the initial dose escalation protocol in the Ozempic Summary of Product Characteristics (SmPC) and helps your body readjust to the medication's effects on gastric emptying and appetite

The exception would be studies measuring acute cognitive performance during active compound presence, where interruption would directly impact measured outcomes

Semaglutide GLP-1 works by increasing feelings of fullness and slowing down gastric emptying, which can lead to a significant reduction in food intake

Mol Cell Endocrinol (2015) 418 Pt 3:2404

Hamashima S, Homma T, Kobayashi S, Ishii N, Kurahashi T, Watanabe R, et al