In a retrospective study, Lyons et al., evaluated the effects of semaglutide in 30 obese patients with HS, reporting reductions in weight, BMI, and metabolic markers such as HbA1c, along with improvements in DLQI and a decreased frequency of flares [160]
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Rapid weight loss from any cause increases bone density concerns, as the mechanical stress from body weight helps maintain bone mass
The team evaluated calibration using estimated CATE quintiles
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