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This review highlights the prevalence, molecular mechanisms and combating approaches of underlying risk conditions by managing endothelial dysfunction, hypertension, and platelet hyperactivity/prothrombotic state with bioactive compounds like polyphenols, small molecules like miRNA, and gene therapy

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The underlying pathophysiology involves intracellular copper accumulation in cardiomyocytes, which directly induces cuproptosis [100]

Infiltrating immune cells either exhibit anticancer responses or create an immunosuppressive environment (105)

Both have been approved for clinical use in Russia since the 1990sSemax for stroke recovery, memory enhancement, and cognitive disorders

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