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Resistant cells generate more glutathione, elicit nuclear factor erythroid 2-related factor 2 (NRF2) activation, and overexpress many anti-oxidative genes such as superoxide dismutase, catalase, glutathione peroxidase, and thioredoxin reductase, providing stronger antioxidant capacity to survive in a more oxidative environment due to the sharp rise in oxidative metabolism and reactive oxygen species generation

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Superoxide dismutase as a target for the selective killing of cancer cells

Figure 13.3 illustrates the structure of four key amino acid neurotransmitters

8.4 Small molecules inducing ferroptosis Resistance to radiotherapy and chemotherapy can lead to treatment failure, making Ferroptosis a new target for traditional treatment (126)

Primary Intracellular Thiol: Serves as a major redox buffer in cells, often present at millimolar levels in many cell types