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Thus, while acute LC supplementation may confer immediate physiological benefits, chronic elevations in TMAO levels warrant careful risk evaluation due to their association with adverse cardiovascular outcomes, particularly in vulnerable populations
This is of particular importance because current anti-fungals are limited in terms of their mechanism of action and all produce serious and treatment-limiting side effects in certain patients
Stay hydrated: Dehydration impairs fat oxidation
Non-steroidal topical therapies targeting phosphodiesterase-4 (PDE4) (e.g., crisaborole ointment) or Janus kinase (JAK) (e.g., ruxolitinib cream, a JAK1/2 inhibitor) have shown efficacy in several case reports of CHE
McDonnell and Dang, 2013
147 On this basis, the restoration of histone acetylation with HDAC inhibitors has prominent tumor suppressor potential, 147,148 and can also synergistically increase the efficacy of radiotherapy, MAPK pathway-targeted therapy, and immunotherapy via the regulation of DNA damage repair, intracellular ROS generation, and programmed death ligand-1(PD-L1) expression, respectively
