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Int J Mol Sci 2022, 23(15)

Clearance of a drug by the liver is determined by hepatic blood flow (Q H ) and the intrinsic ability of the liver to extract the drug (extraction ratio, or ER H ) : Drugs with a high extraction ratio (approaching 1) have Cl H equal to the hepatic blood flow

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Mitochondria show many structural and functional abnormalities in ianimal models and non-alcoholic steatohepatitis (NASH) patients (Sunny et al., 2017)

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