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In this paper we draw from human electronic medical records, rodent behavioral studies, and single cell RNA sequencing to uncover a role for endogenous sex hormone signaling in mediating the differences in efficacy and tolerability between sexes that are observed with GLP1R agonists

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doi: 10.1038/ni.3808 296 NaffaaMERosenbergVWatadATiosanoSYavneYChodickGet al

Ideally, it goes between 500-3000 mg per day