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Reliance on a single drug, however, is problematic, as the parasites are likely to develop resistance to the drug over time

Carcinogenesis, Mutagenesis, Impairment of Fertility In studies in which mice and rats were administered diazepam in the diet at a dose of 75 mg/kg/day (approximately 6 and 12 times, respectively, the maximum recommended human dose [MRHD = 1 mg/kg/day] on a mg/m2 basis) for 80 and 104 weeks, respectively, an increased incidence of liver tumors was observed in males of both species

Transfected cells were then incubated for 48 h in fresh culture media

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PubMed , Molecular Biology Reports , vol