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Lipoprotein receptor-related protein (LRP) also known as LDLR, expressed in neurons, astrocytes, and endothelial cells in the brain functions as a receptor for tPA, mediating MMP upregulation, which in turn can contribute to hemorrhagic transformation from degradation of the neurovascular matrix (Lee et al., 2012)

Renal cell apoptosis induced by nephrotoxic drugs: cellular and molecular mechanisms and potential approaches to modulation

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Meanwhile, chlorthalidone was also effective in treating hypertension, as seen in the large ALLHAT trial (Elliott, 1996), which compared different blood pressure medications

Other common metastatic sites include the lungs, liver, bones, and brain