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Health Technol Assess 2004

Understanding these variables helps contextualise any changes observed during treatment and prevents unnecessary anxiety

The American College of Rheumatology guidelines emphasize weight loss as a core non-pharmacological intervention for overweight and obese patients with knee osteoarthritis, with evidence supporting that even modest weight reduction (5-10% of body weight) can produce clinically meaningful improvements in pain and function

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Third, residual confounding from unmeasured factors such as smoking status, alcohol intake, family history of cancer, and dietary patterns may have influenced the observed associations but could not be adjusted for in this aggregate-level analysis

These broadened prescribing criteria for Ozempic mean that more people will experience severe side effects from the drug