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Studies combining GLP-1 with muscle-protective agents demonstrate superior body composition outcomes compared to GLP-1 therapy alone, with better preservation of lean mass and improved metabolic parameters

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Nerve Dependence on Metabolism: Peripheral nerves require specific nutrient levels Dramatic metabolic changes may temporarily affect nerve function Similar to diabetes causing neuropathy (but reversed mechanism) Weakness of Theory: Improving metabolic health should help nerves, not harm them

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The mechanism by which IGF-1 promotes skin health involves several cellular processes

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3 Neuroscience and Mental Health Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada

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