Williams LM, Debattista C, Duchemin AM, Schatzberg AF, Nemeroff CB
Specific Kidney Effects GLP-1 medications produce several kidney-relevant improvements: Reduced albuminuria: The amount of albumin (protein) in urine, an early marker of kidney damage, typically decreases with GLP-1 treatment
It directly stimulates pro-opiomelanocortin/cocaine-and-amphetamine-regulated transcript (POMC/CART) neurons and indirectly inhibits neuropeptide-Y/agouti-related protein (NPY/AgRP) neurons through GABA neurotransmission, reducing appetite and promoting weight loss [40]
Detoxification support Glutathione is essential for liver detox pathways, helping the body process and eliminate toxins more efficiently
Over 29 days of treatment, the peptide inhibited pulmonary artery muscularization (the thickening and stiffening of pulmonary arteries that drives this condition), prevented right heart hypertrophy (the enlargement of the right ventricle that occurs when it has to pump against increased resistance), and significantly decreased mortality
10.1016/j.nut.2014.03.017 Nutrition
