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A 2004 follow-up confirmed the fibroblast data and added observations on cell division capacity

In vitro permeation and in vivo adsorption testing confirmed that RGD-GHK achieved a high local concentration in the skin layer, initiating peptide effects and facilitating in vivo wound healing, while maintaining excellent biocompatibility

This is particularly significant for patients with fatty liver disease, metabolic syndrome, or those recovering from illness, where this clearance function is often impaired

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