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adults now classified as obese and more than 70% overweight
a phosphoinositide 3-phosphatase) and KEAP1 has an additive effect on NRF2 activity (Taguchi and Yamamoto, 2017)
Development of AngIV-based analogs Given the above research findings regarding Nle-AngIVs ability to facilitate synaptogenesis and memory consolidation via stimulating the HGF/c-Met system in animal models of AD AngIVbased pharmaceuticals have been proposed as therapeutic agents to treat AD (reviewed in [45,92])