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Compared to short-acting GLP-1 analogs (such as exenatide bidaily), long-acting analogs are associated with less nausea and vomiting but with a greater prevalence of diarrhea [734] 20.2

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The activity of these enzymes generates carlactone, the key intermediate to produce SLs

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Additionally, not eating enough solid foods (which also contain water) reduces overall fluid intake

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