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The FDA did attach a boxed warning for embryo-fetal toxicity, flagging the risk of major birth defects when used during pregnancy

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Regarding GLP-1-related mechanisms influencing AUD susceptibility or progression, a genetic study comprising four human association analyses demonstrated that the GLP-1 receptor 168Ser allele correlates with increased alcohol self-administration and heightened functional magnetic resonance imaging blood-oxygen-level-dependent responses in the globus pallidus during a monetary incentive delay task