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In some embodiments, the otic pharmaceutical formulation comprises between about 90% to about 99.9% by the weight of the triglycerides

[14] In severe or inherited forms of biotin deficiency (such as biotinidase deficiency), even higher daily doses may be employed, and lifelong supplementation can be necessary under medical guidance

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It is better understood as one possible biochemical contributor that may amplify oxidative stress, mitochondrial dysfunction and medication sensitivity

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The crosstalk between the above signaling pathways regulates transcription factors responsible for controlling the expression of hyphal-specific genes such as als3 [adhesin] [79], h wp1 [invasin] [80], and h gc1 [hypha-specific cyclin] [81]