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In some embodiments, the otoprotectant is a compound comprising a urea-thiophene-carboxamide moiety of Formula (III): wherein X is a heteroatom that includes N, O, or S
S., Park, M
J.PrangnellS
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Effects on telomere integrity Biomarkers that have been used to quantify ovarian ageing include sinus follicle counting (AFC) and anti-Mllerian hormone (AMH) levels in clinical applications [67]
A similar analysis found that the changes in BUN/Creatinine from beginning of phase 1 to beginning of phase 2 could be partially predicted (adjusted R 2 = 0.51, p = 0.05, with the most significant factors being 9 th dose Hg (p = 0.01), change in glutathione (p = 0.02), 9 th dose Tl (p = 0.04), and 9 th dose Pb (p = 0.05)
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