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Yang J, Huang J, Dasgupta M, Sears N, Miyagi M, Wang B, Chance MR, Chen X, Du Y, Wang Y, An L, Wang Q, Lu T, Zhang X, Wang Z, Stark GR (2010) Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes

2019;9(4):e12323

The STEP program (including STEP 1 and related trials) demonstrated clinically meaningful weight loss across populations and established semaglutide as a new standard for many patients with obesity

The FDA also recommends examining hard clinical endpoints such hepatic decompensations, transplant free survival, and all-cause mortality, although these results are not necessarily needed prior to drug approval given the long length of follow up potentially required

But heres the good news: up to 80% of appeals succeed

Tell your healthcare provider if you have changes in vision during treatment with Wegovy increased heart rate