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It has been found that treating RPE cells with high-concentration glucose solution (30 mM) increases ROS levels, promotes cell ferroptosis, and inhibits cell proliferation and vitality in RPE

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Ketone ester treatment of the 3xTgAD Alzheimers mice reduced the hippocampal mitochondrial [NAD + ]/[NADH] as indicated by the reduced acetoacetate/beta-hydroxybutyrate that changed from 9.3 to 3.4 (2.7-fold decrease), while there was no significant change in this ratio in the cerebral cortex (Pawlosky et al., 2017)

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