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Because pediatric patients were never included in most clinical trials for these drugs, plaintiffs argue that prescribing them off-label created unacceptable dangers

In a non-randomized pilot study, Nikolaidis et al

Dose escalation and what to expect at each level GLP-1 therapy always begins with a lower dose and escalates over weeks to months

The reason is that drugs deliver synthetic appetite-suppressing chemical messengers like GLP-1, GIP, and glucagon agonists at levels astronomically higher than normally produced by the body

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