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Oxidative stress affects numerous molecular pathways, including inhibition of the cystine/glutamate antiporter system, decreased expression of GPX4, disruption of iron homeostasis and lipid peroxidation, which is a major driver of ferroptosis activation (54)
Chromium is usually well tolerated at typical doses
K., Rughu V
Adiponectin inhibits insulin function in primary trophoblasts by PPAR-mediated ceramide synthesis
Hence, therapeutic strategies aimed at enhancing glial GSH synthesis or exporting ability may help modulate glial-immune phenotypes, reduce microglial activation, and slow progressive CNS degeneration in neurodegenerative diseases (Figure 2)
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