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Gindri IM, Ferrari G, Pinto LPS, Bicca J, et al

One of the most common side effects reported for all GLP-1R agonists is malaise ( 5 Future directions and summary As summarized previously, GLP-1R, and to some extent the peptide itself, influences the behavioral and neurochemical outcomes of alcohol and addictive drugs, such as nicotine, opioids, amphetamine, and cocaine

Data from the surpass trial series revealed that tirzepatide reduces the risk of major adverse cardiovascular events and improves blood pressure, lipid profiles, and inflammatory markers (60, 61)

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Conclusions The discovery and application of the incretin hypothesis and the associated pharmacological development of multi-receptor agonists have resulted in unprecedented advancements in anti-obesity interventions