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J Immunol (1994) 153(3):127180

Chronobiology and Pharmacologic Modulation of the Renin-Angiotensin-Aldosterone System in Dogs: What Have We Learned

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43 This suggests that this mtDNA mutation is a risk factor that requires interactions with nuclear mutations, polymorphisms or epigenetics and/or environmental triggers or modulators in order for the disease phenotype to be expressed