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For each outcome, absolute risk, risk difference, risk ratio, and odds ratio were calculated with corresponding 95% confidence intervals

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Lifestyle interventions (including diet, exercise and behavioural changes) are the cornerstone of obesity management with diverse benefits, but even the most intensive lifestyle interventions result in up to 10% mean weight loss (WL) and weight maintenance remains a challenge, as 80% of WL is expected to be regained over the next 5 years [4, 5]

They also launched lawsuits against compounders and called on the FDA to enforce their patent exclusivity