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The peptide functions as a precision senolytic agent by competing with endogenous FOXO4 for p53 binding, releasing the tumor suppressor protein to trigger apoptosis specifically in cells that have accumulated the senescence-associated secretory phenotype (SASP) markers

The lack of MRS dACC changes in the Recent onset group in this or other studies does not amount to a decisive refutation of the glutamate neurotoxicity hypothesis because the relationship of static MRS glutamate to synaptic status is too uncertain and the time of onset of the putative glutamate excess relative to psychosis onset is unknown

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Goutzourelas, N., Orfanou, M., Charizanis, I., Leon, G., Spandidos, D

The ShapiroWilk test was employed to evaluate the normality of the data distribution