O-GlcNAcylation and Huntingtons disease Huntingtons disease (HD) is a rare, hereditary neurodegenerative disorder featured by progressive neurodegeneration, leading to progressive motor dysfunction and cognitive decline
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The lack of effect of specific overexpression of IGF-1 in the central nervous system or skeletal muscle on pathophysiology in the G93A SOD-1 mouse model of ALS
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