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In PCa cells, the activation of GLP-1-R triggers the cAMP cascade, inhibiting extracellular-signal-regulated kinases (ERK) and Cyclin D1, essential for DNA replication and cell cycle progression
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Aunque los medicamentos GLP-1 fueron desarrollados originalmente para la diabetes tipo 2, ahora se utilizan ampliamente para tratar la obesidad y el sndrome metablico
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