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No clinical trials have specifically investigated this combination, and the interactions discussed below remain theoretical

Planning extra electrolyte support around injection day can reduce the impact

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Curcumin 500 mg/day (with 5 mg piperine) for 4 months produced a slight but significant HbA1c decrease but no improvement in fasting blood sugar, insulin, or HOMA-IR in 61 people with type 2 diabetes [75]

The risk of NAION is very rare compared to the massive reduction in cardiovascular events and overall mortality seen in GLP-1 trials