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In March 2026, Structure reported 44-week topline data from the ACCESS II Phase 2 study, showing placebo-adjusted weight loss of up to 16.3%, which the company described as the highest efficacy demonstrated among oral GLP-1 receptor agonists at that time point

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Researchers used propensity scores to match the groups with each other based on baseline demographic characteristics, BMI categories, asthma severity proxies, prior use of asthma-related medications and prior use of diabetes-related medications

Huang, A.A

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The leptin signalling pathway involves binding to specific receptors (ObR) in the hypothalamus, particularly in the arcuate nucleus