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For persistent symptoms, treatment options include: Alginate preparations (such as Gaviscon) that form a protective barrier on top of stomach contents H2-receptor antagonists (such as ranitidine) that reduce acid production Proton pump inhibitors (PPIs) such as omeprazole or lansoprazole for more significant acid suppression NICE guidance supports a 48 week trial of PPIs for reflux symptoms, with periodic review for long-term use